Cathepsin L Rat anti-Human, Mouse, Clone: 204101, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA523891
In direct ELISAs and Western blots, no cross-reactivity with recombit human Cathepsin B, C, L2, O, S, or X/Z/P is observed. In Western blots, both the pro and active forms of recombit human and mouse Cathspsin L are recognized. Reconstitute at 0.5 mg/mL in sterile PBS.The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene.
|PBS with 5% trehalose and No Preservative|
|1190035F06Rik, Ctsl1, MEP, fs, nkt|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry, Immunoprecipitation, Western Blot|
|Mouse myeloma cell line NS0-derived recombit human Cathepsin L Glu113-Val333|
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