Caveolin-1 (pY14) Mouse, Unlabeled, Clone: 56, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 611339

Catalog No. BDB611339

Description

Caveolin (VIP21) localizes to non-clathrin membrane invaginations (caveolae) on the inner surface of the plasma membrane. In addition, it is present in the trans-Golgi network (TGN) and in apically and basolaterally destined transport vesicles. Caveolin is a transmembrane adaptor molecule that recognizes GPI-linked proteins and interacts with downstream cytoplasmic signaling molecules, such as src-family tyrosine kinases and hetero-trimeric G proteins. Caveolin forms large lipid-binding oligomers, which are thought to play a role in caveolae formation. It may also function as a scaffolding protein, which organizes signaling molecules. This functional role is supported by the fact that caveolin interacts directly with inactive ras and G-protein α subunits. Phosphorylation of caveolin at Tyr-14, Ser-88, and other residues in v-src transformed cells leads to flattening, aggregation, and fusion of caveolae and caveolae-derived vesicles. Thus, caveolin is the principle protein of caveolae and may be involved in v-src mediated cellular transformation.

Host Species: Mouse
Clone: 56
Isotype: IgG1
Species Reactivity: Human
Immunogen: Phosphorylated Human Caveolin-1 (Y14) Peptide
Formula Weight [Chemical]: 21-24kDa

Flow Cytometry, Immunofluorescence, Immunohistochemistry, Intracellular Staining, Western Blotting

Specifications

• Antigen: Caveolin-1 (pY14)
• Classification: Monoclonal
• Concentration: 250μg/mL
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Immunogen: Phosphorylated Human Caveolin-1 (Y14) Peptide
• Quantity: 150 μg
• Research Discipline: Cell Biology
• Target Species: Human, Mouse, Rat
• Isotype: IgG1

• Applications: Western Blot
• Clone: 56
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

For Research Use Only.