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CBF beta Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1317

Catalog No. 01-670-101


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Description

Description

PA1-317 detects CBF-beta in human samples. PA1-317 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~22 kDa protein representing CBF-beta in HeLa whole cell lysates. The PA1-317 immunogen is a synthetic peptide corresponding to residues M(1) P R V V P D Q R S K F E N E E F F R K(20) of human CBF beta. This sequence is conserved in mouse. PA1-317 immunizing peptide (Cat. No. PEP-282) is available for use in neutralization and control experiments.

CBF-beta (Core-binding factor beta), also called polyomavirus enhancer binding protein 2 beta (PEBP2B), belongs to the PEBP2/CBF transcription factor family which regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). CBF-beta is associated with an inversion of chromosome 16 and is associated with acute myeloid leukemia in humans. CBFbeta forms a heterodimer with RUNX1 (runt-related transcription factor 1), which has a DNA binding domain homologous to the pair-rule protein runt in Drosophila melanogaster. Both RUNX1 and CBFbeta are essential for hematopoiesis. Haploinsufficiency of another runt-related protein, RUNX2 (also called CBFA1), causes cleidocranial dysplasia in humans and is essential in skeletal development by regulating osteoblast differentiation and chondrocyte maturation. CBF-beta is expressed in all tissues tested. CBF-bet is highly expressed in the thymus, but also abundantly expressed in muscle, lung and brain.
Specifications

Specifications

CBF beta
Polyclonal
Unconjugated
CBFB
Liquid
CBFB
Synthetic peptide corresponding to residues M(1) P R V V P D Q R S K F E N E E F F R K(20) of human CBF beta.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
Q13951
Core-binding factor subunit beta, Polyomavirus enhancer-binding protein 2 beta subunit, PEBP2-beta, PEA2-beta
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
865
Documents
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