Cbl-b Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527692
PA5-27692 targets Cbl-b in WB applications and shows reactivity with Human samples. The PA5-27692 immunogen is recombit fragment corresponding to a region within amino acids 735 and 980 of Human Cbl-b. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization.
|Recombit fragment corresponding to a region within amino acids 735 and 980 of Human Cbl-b|
|Antigen affinity chromatography|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|Cbl-b, RNF56, Cas-Br-M (murine) ectropic retroviral transforming sequence b, E3 ubiquitin-protein ligase CBL-B, RING finger protein 56, SH3-binding protein CBL-B, casitas B-lineage lymphoma proto-oncogene b, signal transduction protein CBL-B|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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