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c-Cbl Goat anti-Mouse, Polyclonal, Invitrogen™

Goat Polyclonal Antibody

Manufacturer:  Invitrogen PA19022

Catalog No. 01-674-606


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Description

Description

This antibody is predicted to react with bovine, canine, human, porcine and rat based on sequence homology.

Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The  ft.Tyr-731 ft. phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
Specifications

Specifications

c-Cbl
Polyclonal
Unconjugated
Cbl
Liquid
CBL
Synthetic peptide corresponding to the C terminus amino acids REFVSISSPAHVAT.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Mouse
Western Blot
0.5 mg/mL
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
P22682
CBL; CBL2; C-CBL; RNF55; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Cas-Br-M ecotropic retroviral transforming sequence (Oncogene C
Goat
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
12402
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