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c-Cbl Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA511356

Catalog No. PIPA511356

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
Specifications

Specifications

c-Cbl
Polyclonal
PBS with 0.09% sodium azide
P22681
Signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3; RING finger protein 57; RNF57; CBLC
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
867
Immunohistochemistry, Western Blot
Unconjugated
CBL
Liquid
CBL
KLH conjugated synthetic peptide between 424-453 amino acids from the C-terminal region of human CBLC
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Documents
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