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CBX4 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA512200

Catalog No. PIPA512200


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Description

Description

This antibody is predicted to react with mouse based on sequence homology.

Chromobox homolog 4 (CBX4 or Pc2) is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintece of appropriate expression patterns of developmental master regulators and thus are essential for proper development. Changes in expression pf PcG proteins have been associated with cancer. CBX4 is a part of the cellular memory system that is responsible for the inheritance of gene activity by progeny cells. CBX4 is involved in maintaining the transcriptionally repressive state of genes. It modifies chromatin, rendering it heritably changed in its expressibility. Structurally, CBX4 contains 1 chromo domain. It was reported that Pc2 is involved in sumoylation process by recruiting SUMO E1 and E2, and Pc2 is actually SUMO E3 during sumoylation events. CBX4 expression is ubiquitous.
Specifications

Specifications

CBX4
Polyclonal
PBS with 0.09% sodium azide
O00257
Chromobox protein homolog 4, Polycomb 2 homolog, Pc2, hPc2
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
8535
Western Blot
Unconjugated
CBX4
Liquid
CBX4
KLH conjugated synthetic peptide between 410-437 amino acids from the C-terminal region of human CBX4
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human
Documents
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