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CTCF Rabbit anti-Canine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141663

Catalog No. 01-675-272


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Description

Description

Suggested positive control: HeLa nuclear extract.

Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain containing, DNA-binding nuclear phosphoprotein that is involved in multiple aspects of normal gene regulation including transcriptional repression and activation, gene silencing, chromatin insulation and regulation of imprinted sites. CTCF uses different combinations of ZF domains and interacts with the CCCTC motif on the DNA. It can bind to HAT- and HDAC-containing complexes thereby influencing transcriptional activation or repression respectively. It is a multifunctional protein involved in the transactivation of APPB gene, silencing of c-myc gene, and insulation of human beta-globin and DMI myotonic dystrophy locus and imprinting control of IGF2 and H19 regions. CTCF has also been shown to regulate the transcription of Pax6 and IRAK2 promoter thereby opening a therapeutic avenue. Mutations in this gene have been associated with invasive breast cancers, prostate cancers and Wilms’ tumors.
Specifications

Specifications

CTCF
Polyclonal
Unconjugated
CTCF
Liquid
CTCF
Synthetic peptide corresponding to residues 650-700 of human CTCF.
Protein G
RUO
Antibody
Polyclonal
Canine, Human, Mouse, Non-human primate, Rat
Western Blot
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
P49711, Q61164, Q9R1D1
CTCF
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
10664, 13018, 479684, 83726
Documents
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