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CCL4 Mouse anti-Human, Clone: 24006, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523713

Catalog No. PIMA523713


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Description

Description

In Western blots, this antibody shows less than 4% cross-reactivity with recombit human (rh) CCL3/MIP-1 alpha and does not cross-react with recombit mouse (rm) CCL3/MIP-1 alpha, rmCCL4/MIP-1 beta, rhCXCL8/IL-8, rhCCL5, rhCXCL1, rhCXCL2, or rhCXCL3. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

CCL4 (macrophage inflammatory protein 1-beta, MIP1B) belongs to the intercrine beta (chemokine CC) family. Functionally, CCL4 is involved in chemotactic and proinflammatory effects, and homeostasis. CCL4 is produced by macrophages upon stimulation by bacterial endotoxins. CCL4 recruits and stimulates various inflammatory cells at sites of inflammation. CCL4 is produced by lymphocytes, macrophages and dendritic cells. Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells. While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ, with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes. Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells. CCL4 binds with high affinity to CCR5 receptors.
Specifications

Specifications

CCL4
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P13236
C-C motif ligand 4, macrophage inflammatory protein 1-beta, MIP1-beta, MIP1B, MIP1B1, ACT2, AT744.1, G-26, HC21, lymphocyte-activation gene 1, LAG-1, LAG1, SCYA2, SCYA4
Mouse
IgG2b
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
6351
ELISA, Flow Cytometry, Neutralization, Western Blot
24006
Unconjugated
CCL4
Lyophilized
CCL4
Sf 21-derived recombit human CCL4/MIP-1 beta Ala24-Asn92
Protein A/G
RUO
Antibody
Monoclonal
Human
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