CCL4 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523681
DescriptionCCL4 (macrophage inflammatory protein 1-beta, MIP1B) belongs to the intercrine beta (chemokine CC) family. Functionally, CCL4 is involved in chemotactic and proinflammatory effects, and homeostasis. CCL4 is produced by macrophages upon stimulation by bacterial endotoxins. CCL4 recruits and stimulates various inflammatory cells at sites of inflammation. CCL4 is produced by lymphocytes, macrophages and dendritic cells. Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells. While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ, with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes. Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells. CCL4 binds with high affinity to CCR5 receptors.
|KLH conjugated synthetic peptide between 22-48 amino acids from the central region of human CCL4|
|Antigen Affinity Chromatography, Protein A|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.09% sodium azide|
|ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4, C-C motif chemokine 4, CC chemokine ligand 4, G-26 T-lymphocyte-secreted protein, MIP-1-beta(1-69), PAT 744, SIS-gamma, T-cell activation protein 2, lymphocyte activation gene 1 protein, lymphocyte-activation gene 1, macrophage inflammatory protein 1-beta, secreted|
|-20° C, Avoid Freeze/Thaw Cycles|
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