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Cyclin T1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA524163

Catalog No. PIPA524163

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
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CCNT1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.


Cyclin T1
PBS with 0.09% sodium azide
O60563, Q9QWV9
CCNT, CYCT1, HIVE1, CDK9-associated C-type protein, Human immunodeficiency virus-1 expression, cyclin C-related protein, cyclin T1b, cyclin-T, cyclin-T1, human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1, subunit of positive elongation transcription factor b
400 μL
-20° C, Avoid Freeze/Thaw Cycles
12455, 904
Flow Cytometry, Western Blot
KLH conjugated synthetic peptide between 253-281 amino acids from the central region of human CCNT1
Protein A, Antigen Affinity Chromatography
Human, Mouse
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