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CCR2 Polyclonal Antibody, Invitrogen™

CCR2 Antibody, PA1-27409, from Invitrogen™. Species Reactivity: Human, Mouse, Rat; Applications: FACS, ICC, IF, IHC (Paraffin), WB.

Manufacturer:  Invitrogen PA127409

Catalog No. PA127409

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

CCR2 Antibody, PA1-27409, from Invitrogen. Species Reactivity: Human, Mouse, Rat; Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot.

CCR2, or C-C chemokine receptor type 2, is a receptor for several monocyte chemo-attractant proteins (MCP1, MCP3, MCP4) which specifically mediate monocyte chemotaxis. CCR2 transduces such signals by increasing the intracellular level of clcium ions. For example, MCP1 is involved in monocyte infiltration in inflammatory diseases such as rheumatiod arthritis as well as in the inflammatory response against tumors. CCR2 is also an alternative coreceptor with CD4 for HIV-1 infection. CCR2 has two isoforms and has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen and thymus.
Host Species: Goat
Cross Reactivity: Human, Mouse, Rat
Isotype: IgG
Immunogen: Synthetic peptide corresponding to the N-terminal residues S(18) H S L F T R S I Q E L D E G A T T P Y D Y D D G E P C(45) of mouse CCR2
Formulation: 100µg purified antibody (1mg/mL) in 0.01M potassium phosphate with 0.14M NaCl, 1mg/mL BSA and 0.1% sodium azide; pH 7.2
Synonyms: CC-CKR-2, CCR2A, CCR2B, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R, C-C Chemokine Receptor 2
Uniprot Accession: O55193, P41597, P51683
Entrez GeneID: 12772, 60463, 729230
Gene Symbol: CCR2
PA1-27409 detects CCR2 from mouse samples. PA1-27409 has been successfully used in immunohistochemistry (paraffin), immunocytochemistry, flow cytometry, and Western blot procedures. The PA1-27409 immunogen is a synthetic peptide corresponding to the N-terminal residues S(18) H S L F T R S I Q E L D E G A T T P Y D Y D D G E P C(45) of mouse CCR2
References:
Test: IHC, Dilution: 1:100, Species: Ms, Reference: MCP-1/CCR2 signaling-mediated astrocytosis is accelerated in a transgenic mouse model of SOD1-mutated familial ALS. (2013) Acta Neuropathol Commun, Vol: 1, , 21, Kawaguchi-Niida M,Yamamoto T,Kato Y,Inose Y,Shibata N; Pubmed ID: 24252211
Specifications

Specifications

CCR2
Polyclonal
100μg purified antibody (1mg/mL) in 0.01M potassium phosphate with 0.14M NaCl, 1mg/mL BSA and 0.1% sodium azide; pH 7.2
Purified
CCR2
Synthetic peptide corresponding to the N-terminal residues S(18) H S L F T R S I Q E L D E G A T T P Y D Y D D G E P C(45) of mouse CCR2
100μg
Store at -80°C, Avoid Freeze/Thaw Cycles
Primary
12772, 60463, 729230
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
O55193, P41597, P51683
CC-CKR-2, CCR2A, CCR2B, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R, C-C Chemokine Receptor 2
Goat
IgG
RUO
Primary
Polyclonal
Human, Murine, Rat
Documents
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