CCR3 Goat anti-Human, Polyclonal, Invitrogen
Goat Polyclonal Antibody
Manufacturer: Invitrogen PA121622
PA1-21622 detects CCR3 in human samples. PA1-21622 has been successfully used in ELISA, immunocytochemistry, immunohistochemistry (paraffin) and Western blot procedures. The PA1-21622 immunogen is a synthetic peptide corresponding to residues C V E T F G T T S Y Y D D V G L L C E K A D T R A L M A of human CCR3. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.CCR3 (C-C chemokine receptor type 3) binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1 delta. CCR3 trasnduces a signal by increasing the intracellular calcium ions level. It also serves as an alternative co-receptor with CD4 for HIV-1 infection. Other chemokines play important roles in inflammation and are critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines.
|Synthetic peptide corresponding to residues C V E T F G T T S Y Y D D V G L L C E K A D T R A L M A of human CCR3.|
|Antigen affinity chromatography|
|ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 1mg/mL BSA and 0.1% sodium azide; pH 7.2|
|CC-CKR-3, CKR3, CMKBR3, MGC102841|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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