CD105 Mouse anti-Human, BUV395, Clone: 266, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 563803

Catalog No. BDB563803

Description

The 266 monoclonal antibody specifically binds to CD105. CD105 presents an integral membrane homodimer protein with subunits of 95 kDa found on vascular endothelial cells and syncytiotrophoblasts of placenta. CD105 is weakly expressed on stromal fibroblasts. It is also expressed on U937 cells, activated macrophages, and mesenchymal stem cells. CD105 is a component of the TGF-β receptor system in human umbilical vein endothelial cells and binds TGF-β1 and TGF-β3 with high affinity but does not bind toTGF-β2. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation.

The antibody was conjugated to BD Horizon™ BUV395 which has been exclusively developed by BD Biosciences as an optimal dye for use on a 355nm laser equipped instrument. With an Ex Max at 348 nmand an Em Max at 395nm, this dye has virtually no spillover into any other detector. BD Horizon™ BUV395 can be excited with a 355nm laser and detected with a 379/28 filter.

Specifications

• Antigen: CD105
• Classification: Monoclonal
• Conjugate: Brilliant Ultraviolet 395
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Immunogen: Human CCR10 Transfected Cell Line
• Quantity: 50 Tests
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: 266
• Description: Endoglin; ENG; END; HHT1; ORW; ORW1
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG1 κ