Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

CD117 Mouse anti-Human, Unlabeled, Clone: 28/CD117, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 612318

Catalog No. BDB612318

Add to cart



c-Kit, a type III tyrosine kinase receptor, binding of stem cell factor (SCF) is involved in the regulation of a wide range of tissues at various developmental stages. c-Kit is a 145 kD protein with an N-terminal domain containing an extracellular domain and a transmembrane domain (TMD) typical of a transmembrane receptor kinase and has been renamed as CD117 with the new nomenclature . SCF and c-kit play a major role in regulation of human haematopoiesis as evidenced by increases in c-kit expression when erythroid differentiation is inhibited with basic fibroblast growth factor. Activating mutations of c-kit are associated with sporadic adult human mastocytosis (SAHM), gastrointestinal stromal tumors (GIST), acute myeloid leukemia (AML), and germ cell tumors. Activation of STAT-3 may be a key requirement for c-kit tumorigenicity. Human germ cell proliferation and survival are highly dependent on c-kit expression and genetic mutations of c-kit result in infertility, disruption of spermatogenesis, and some testicular disorders. Blockage of SCF binding to c-kit via inhibitors of the ligand may be a viable clinical approach in management of GIST and possibly other diseases. Thus, c-kit plays a major role in reproductive development and in many human diseases, including various cancers.



Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Western Blot
Affinity Purified
Human c-Kit aa. 1-115
Store undiluted at -20°C.
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit