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CD11a Mouse anti-Human, FITC, Clone: MEM-25, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119559

Catalog No. 01-676-289


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Description

Description

CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions. Blocking of LFA-1 function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases. For example, humanized anti-LFA-1 antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation; binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity.

Specifications

Specifications

CD11a
Monoclonal
FITC
PBS with 0.2% BSA and 15mM sodium azide
P20701
CD11 antigen-like family member A, LFA-1 alpha, LFA-1A, antigen CD11A p180, lymphocyte function-associated antigen 1 alpha polypeptide, integrin alpha-L
Mouse
IgG1
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
3683
Flow Cytometry
MEM-25
Assay Dependent
ITGAL
Liquid
ITGAL
Leucocytes from a patient suffering from a LGL type leukaemia.
Purified
RUO
Antibody
Monoclonal
Human
Documents
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