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CD11b Mouse anti-Human, Clone: F6.2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112199

Catalog No. 01-670-909


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Description

Description

CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.
Specifications

Specifications

CD11b
Monoclonal
Unconjugated
ITGAM
Liquid
ITGAM
White blood cells.
Protein A/G
RUO
Antibody
Monoclonal
Human
Flow Cytometry
F6.2
PBS with 0.08% sodium azide
P11215
CD11B, CR3A, MAC-1, MAC1A, MGC117044, MO1A, SLEB6, Integrin alpha M
Mouse
IgG2a
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
3684
Documents
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