MilliporeSigma™ anti-CD11b FITC, Clone: M1/70,

Rat Monoclonal Antibody

Supplier:  MilliporeSigma™ MABF801

Catalog No. MABF801MI

Description

Specifically detects CD11b Clone: M1/70 in Human, Mouse samples, and it is validated for Flow Cytometry

The M1/70 antibody reacts with human and mouse CD11b, also known as integrin alpha M. This 165-170kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alphaM (CD11b) assembles with Integrin beta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The M1/70 antibody is widely used as a marker for CD11b expression on mouse macrophages, granulocytes, neutrophils, and NK cells. The antibody is also reported to be cross-reactive for Rhesus macaque CD11b.

Specifications

• Antigen: CD11b
• Classification: Monoclonal
• Conjugate: FITC
• Gene Accession No.: P05555
• Host Species: Rat
• Purification Method: Purified by size-exclusion chromatography
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: 2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
• Isotype: IgG2b κ

• Applications: Flow Cytometry
• Clone: M1/70
• Formulation: Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
• Gene Symbols: Itgam
• Immunogen: Proprietary immunogen
• Quantity: 100 μg
• Research Discipline: Inflammation, Immunology
• Target Species: Human, Mouse
• Form: Purified

For Research Use Only