CD13 Rat anti-Mouse, Alexa Fluor 647, Clone: R3-242, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 564352
The R3-242 monoclonal antibody specifically binds to aminopeptidase N (APN), which has been reported to be the mouse CD13 homologue. APN is expressed in a variety of mammalian tissues, including intestinal and renal epithelial brush border, endothelium, liver, lung, and brain. In lymphoid tissues, R3-242 mAb is reported to detect APN on monocytes, macrophages, mast cells, dendritic cells, and B lymphocytes, but not on T cells, and thymocytes. However, the reported reactivity with B cells may be non-specific, via binding to the Fc γreceptors (CD16/CD32). This observation is in agreement with reports using different antibodies to mouse APN . APN may play a role in antigen presentation in the immune system. R3-242 mAb does not inhibit the enzymatic activity of APN.
|Alexa Fluor 647|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Anpep; Alanyl aminopeptidase; Aminopeptidase N; AP-N; mAPN; Lap-1|
|Crude Aminopeptidase N Preparation from BALB/c Mouse Intestinal Epithelium|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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