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GP130 Rat anti-Mouse, Clone: 125623, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA523922
In Western blots, no cross-reactivity with Recombinant human gp130 is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
|PBS with 5% trehalose and No Preservative|
|CD130, CDw130, GP130, GP130-RAPS, IL6R-beta, IL6ST|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence|
|Mouse myeloma cell line NS0-derived recombit mouse gp130 Gln23-Glu617 (predicted)|
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