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CD14 Mouse anti-Human, Non-human primate, Biotin, Clone: MEM-15, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119514

Catalog No. 01-676-248


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Description

Description

CD14 is a 55 kDa GPI-anchored glycoprotein that is constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils. CD14 also serves as a multifunctional lipopolysaccharide receptor, and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 can discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. Further, CD14 has been shown to bind apoptotic cells, and can affect allergic, inflammatory and infectious processes. Alternative splicing results in multiple transcript variants encoding the same CD14 isoform. Diseases associated with CD14 dysfunction include mycobacterium chelonae infection and Croup.
Specifications

Specifications

CD14
Monoclonal
1 mg/mL
PBS with 15mM sodium azide; pH 7.4
P08571
monocyte differentiation antigen CD14, myeloid cell-specific leucine-rich glycoprotein
Mouse
IgG1
100 μg
4° C, do not freeze
Primary
929
Flow Cytometry
MEM-15
Biotin
CD14
Liquid
CD14
Human urinary proteins from the urine of a patient suffering from proteinuria.
Purified
RUO
Antibody
Monoclonal
Human, Non-human Primate
Documents
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