CD140b Mouse anti-Human, Unlabeled, Clone: 28, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610113
Platelet-derived growth factor (PDGF) is a potent mitogen for cells of esenchymal origin and exerts its effects by binding to the PDGF receptor (PDGFR), a transmembrane protein tyrosine kinase. Both PDGF and PDGFR consist of subunits that form homo- or heterodimers with varying specificities: PDGF-AA binds only to αα PDGFR, PDGF-AB binds to both αα and αβ PDGFR, and PDGF-BB binds to all three PDGFRs. Ligand binding induces phosphorylation and activation of the receptor and, in turn, initiation of an intracellular phosphorylation cascade. PDGFR localizes primarily to membrane invaginations termed caveolae, compartments that are enriched in several of its downstream effectors, including PI3 kinase, Shc, NCK, and PTP1D. Additionally, the β subunit of PDGFR has been implicated in cellular transformation. This effect is mediated by a C-terminal region of PDGFRβ and depends on pathways that involve either PLCβ or PI3 kinase.
Host Species: Mouse
Species Reactivity: Human
Immunogen: Human PDGF Receptor β aa. 1-187
Formula Weight [Chemical]: 180kDa
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
|PDGF Receptor β|
|Human PDGF Receptor β aa. 1-187|
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