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CD140b Mouse anti-Human, Unlabeled, Clone: 28, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610113

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Catalog No. BDB610113


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Description

Description

Platelet-derived growth factor (PDGF) is a potent mitogen for cells of esenchymal origin and exerts its effects by binding to the PDGF receptor (PDGFR), a transmembrane protein tyrosine kinase. Both PDGF and PDGFR consist of subunits that form homo- or heterodimers with varying specificities: PDGF-AA binds only to αα PDGFR, PDGF-AB binds to both αα and αβ PDGFR, and PDGF-BB binds to all three PDGFRs. Ligand binding induces phosphorylation and activation of the receptor and, in turn, initiation of an intracellular phosphorylation cascade. PDGFR localizes primarily to membrane invaginations termed caveolae, compartments that are enriched in several of its downstream effectors, including PI3 kinase, Shc, NCK, and PTP1D. Additionally, the β subunit of PDGFR has been implicated in cellular transformation. This effect is mediated by a C-terminal region of PDGFRβ and depends on pathways that involve either PLCβ or PI3 kinase.

Host Species: Mouse
Clone: 28
Isotype: IgG2b
Species Reactivity: Human
Immunogen: Human PDGF Receptor β aa. 1-187
Formula Weight [Chemical]: 180kDa

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

Specifications

CD140b
28
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG2b
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
PDGF Receptor β
Affinity Purified
Human PDGF Receptor β aa. 1-187
50μg
Immunology
Primary
Human
Documents
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