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CD140b Mouse anti-Human, Unlabeled, Clone: 28, BD

Mouse Monoclonal Antibody

$213.00

Specifications

Antigen CD140b
Isotype IgG2b
Immunogen Human PDGF Receptor β aa. 1-187
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610113
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BD Biosciences
610113
50μg
Each for $213.00
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BDB610114
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BD Biosciences
610114
150μg This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000. N/A
Description

Description

Platelet-derived growth factor (PDGF) is a potent mitogen for cells of esenchymal origin and exerts its effects by binding to the PDGF receptor (PDGFR), a transmembrane protein tyrosine kinase. Both PDGF and PDGFR consist of subunits that form homo- or heterodimers with varying specificities: PDGF-AA binds only to αα PDGFR, PDGF-AB binds to both αα and αβ PDGFR, and PDGF-BB binds to all three PDGFRs. Ligand binding induces phosphorylation and activation of the receptor and, in turn, initiation of an intracellular phosphorylation cascade. PDGFR localizes primarily to membrane invaginations termed caveolae, compartments that are enriched in several of its downstream effectors, including PI3 kinase, Shc, NCK, and PTP1D. Additionally, the β subunit of PDGFR has been implicated in cellular transformation. This effect is mediated by a C-terminal region of PDGFRβ and depends on pathways that involve either PLCβ or PI3 kinase.

Host Species: Mouse
Clone: 28
Isotype: IgG2b
Species Reactivity: Human
Immunogen: Human PDGF Receptor β aa. 1-187
Formula Weight [Chemical]: 180kDa

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

Specifications

CD140b
Human PDGF Receptor β aa. 1-187
Unconjugated
Immunology
Mouse
Affinity Purified
Monoclonal
PDGF Receptor β
IgG2b
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
28
250μg/mL
Store undiluted at -20°C.
SDS
Product Certifications

For Research Use Only.

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