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CD141 Mouse anti-Human, APC, Clone: 1A4, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 564123

Catalog No. BDB564123


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Description

Description

The 1A4 monoclonal antibody specifically binds to CD141. CD141 is a 75 kDa, single chain, type I membrane glycoprotein referred to as thrombomodulin and fetomodulin. CD141 is expressed on endothelial cells, smooth muscle cells, epithelial cells, synovial lining cells, and keratinocytes. It is also found on megakaryocytes, dendritic cells, peripheral blood moncytes, and neutrophils, but not on lymphocytes. Reports indicate that CD141 plays an important role in Protein C activation and the initiation of the Protein C anticoagulant pathway. Thrombin loses its procoagulant function when it binds to CD141, and the CD141/thrombin complex is able to activate Protein C.

Specifications

Specifications

CD141
1A4
Thrombomodulin; TM; THBD; THRM; AHUS6; Fetomodulin; BDCA-3
Affinity Purified
Purified Human Thrombomodulin
100 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
APC
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Murine
IgG1, κ
RUO
Primary
Human
Documents
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