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CD146 Mouse anti-Human, BUV395, Clone: P1H12, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 564326

Catalog No. BDB564326


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Description

Description

The P1H12 monoclonal antibody specifically binds to CD146. CD146 is a 118 kDa transmembrane glycoprotein also known as MCAM, MUC18, or Mel-CAM. CD146 is a member of the immunoglobulin superfamily and is expressed by angioblasts and mesenchymal stems cells and is strongly expressed by blood vessel endothelium and smooth muscle. CD146 is also expressed by melanoma cells, intermediate trophoblasts and a subpopulation of activated T cells. The P1H12 monoclonal antibody has been reported to block endothelial cell adhesion that is observed very early in embryogenesis. It can be useful in the study of embryologic vasculogenesis. This antibody is suitable for immunohistochemical staining of acetone-fixed frozen tissue sections, immunoprecipitation and ELISA.

The antibody was conjugated to BD Horizon BUV395 which is part of the BD Horizon Brilliant™ Ultraviolet family of dyes. This dye is optimal for multicolor flow cytometry because it has little to no spillover into other detectors. With an Ex Max at 348nm and an Em Max at 395nm, BD Horizon BUV395 can be excited with a 355nm laser and detected with a 379/28 filter.

Specifications

Specifications

CD146
P1H12
MCAM; MELCAM; MUC18; Gicerin; Melanoma cell adhesion molecule
Affinity Purified
Human Umbilical Vein Cells
50 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
Brilliant Ultraviolet 395
Aqueous buffered solution containing BSA and ≤0.09% sodium azide
Murine
IgG1, κ
RUO
Primary
Human
Documents
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