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ADAM17 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112517

Catalog No. 01-674-177


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Description

Description

A suggested positive control for this product is HeLa or Jurkat whole cell lysate.

Tumor-necrosis factor-a is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-a is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-a. TNF-a converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFa, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association.
Specifications

Specifications

ADAM17
Polyclonal
PBS with 0.02% sodium azide
P78536, Q9Z0F8, Q9Z1K9
A disintegrin and metalloproteinase domain 17, TNF-alpha-converting enzyme, TNF-alpha convertase, Snake venom-like protease, CD156b antigen, CSVP, TACE
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
11491, 57027, 6868
Western Blot
Unconjugated
ADAM17
Liquid
ADAM17
Synthetic peptide corresponding to residues 807-823 of human TACE.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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