CD16 Mouse anti-Human, Mouse, Rat, Clone: ASH 1975, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA17633
MA1-7633 detects CD16 from human samples and CD16-2 from mouse and rat. MA1-7633 has been successfully used in ELISA, IF, flow cytometry, immunoprecipitation, and immunohistochemistry (frozen sections) procedures. The MA1-7633 immunogen is a CD16 protein. Store at 4°C short term. For extended storage, store at -80°C.CD16 (FCGR3A) is a 50-65 kDa cell surface molecule that exists in two forms - a transmembranous form expressed by NK cells and some T cells, and a phosphatidylinositol linked form expressed by granulocytes. CD16 is a low affinity receptor for IgG (FcR III), and is an important receptor mediating ADCC by NK cells. Human CD16 is expressed in two forms – FCGR3A and FCGR3B. FCGR3A is associated with the FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FCGR3A is associated, with FcepsilonRI-beta subunit. Besides IgG, FCGR3A can be triggered also by oligomeric IgE. FCGR3B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a pro-adhesive phenotype. Diseases associated with CD16 dysfunction include immunodeficiency 20 and systemic lupus erythematosus.
|PBS with 0.01% sodium azide; pH 7.2|
|O75015, P08637, P08508|
|FCGR3A, FCGR3B, CD16A, CD16B, Fc gamma Receptor III, Fc gamma Receptor 3, RP11-5K23.1, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA|
|4°C or -80°C if preferred|
|14131, 2214, 2215, 304966|
|ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation|
|FCGR3, FCGR3A, FCGR3B|
|Human, Mouse, Rat|
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