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CD16 Mouse anti-Human, Clone: J5511, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112041

Catalog No. 01-670-764


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Description

Description

CD16 (FCGR3A) is a 50-65 kDa cell surface molecule that exists in two forms - a transmembranous form expressed by NK cells and some T cells, and a phosphatidylinositol linked form expressed by granulocytes. CD16 is a low affinity receptor for IgG (FcR III), and is an important receptor mediating ADCC by NK cells. Human CD16 is expressed in two forms – FCGR3A and FCGR3B. FCGR3A is associated with the FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FCGR3A is associated, with FcepsilonRI-beta subunit. Besides IgG, FCGR3A can be triggered also by oligomeric IgE. FCGR3B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a pro-adhesive phenotype. Diseases associated with CD16 dysfunction include immunodeficiency 20 and systemic lupus erythematosus.
Specifications

Specifications

CD16
Monoclonal
1 mg/mL
PBS with 0.08% sodium azide
O75015, P08637
FCGR3A, FCGR3B, CD16A, CD16B, Fc gamma Receptor III, Fc gamma Receptor 3, RP11-5K23.1, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
2214, 2215
Flow Cytometry
J5511
Unconjugated
FCGR3A
Liquid
FCGR3A, FCGR3B
NK lymphocytes
Purified
RUO
Antibody
Monoclonal
Human
Documents
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