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CD163 Mouse anti-Human, Clone: 215930, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523788

Catalog No. PIMA523788


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Description

Description

In sandwich ELISAs, no cross-reactivity or interference with recombit mouse (rm) CD163, rmCD6, or recombit human CD6 is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

CD163 (M130 antigen, Ber-Mac3, Ki-M8, SM4) is a 130 kDa membrane glycoprotein, a member of the scavenger receptor cysteine-rich superfamily, and a receptor for the hemoglobin-haptoglobin complex. CD163 protects tissues from free hemoglobin-mediated oxidative damage, and may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. CD163 is expressed exclusively on the cell surface of human monocytes and macrophages that evolve predomitly in the late phase of inflammation. Specifically, CD163 is present on all circulating monocytes and most tissue macrophages except those found in the mantle zone and germinal centers of lymphoid follicles, interdigitating reticulum cells and Langerhan ft.s cells. CD163 is present on all CD14 positive monocytes, most CD64 positive monocytes, and shows higher expression on CD16 positive monocytes. CD163 is upregulated on mononuclear phagocytes by IL-10, IL-6 and dexamethasone. Lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) both induce shedding of CD163 from the cell surface into plasma or cell supernatant. CD163 binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner, and exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP1S phenotype. Further, CD163 also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.
Specifications

Specifications

CD163
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q86VB7
CD163 antigen, hemoglobin scavenger receptor, macrophage-associated antigen, scavenger receptor cysteine-rich type 1 protein M130
Mouse
IgG1
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
9332
ELISA
215930
Unconjugated
CD163
Lyophilized
CD163
Mouse myeloma cell line NS0-derived recombit human CD163 Gly41-Ser1045
Protein A/G
RUO
Antibody
Monoclonal
Human
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