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CD172a/b Mouse anti-Human, PE, Clone: SE5A5, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 563441

Catalog No. BDB563441


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Description

Description

The SE5A5 monoclonal antibody specifically binds to a common epitope on CD172a/ SIRPα (90 kDa) and CD172b/ SIRPβ 1(50 kDa) . These transmembrane glycoproteins are members of the Signal Regulatory Protein (SIRP) family that, in turn, belongs to the Immunoglobulin superfamily. The SIRP family is comprised of two subgroups, SIRPα and SIRPβ that are distinguished by the presence (α) or absence (β) of a cytoplasmic domain containing two immunoreceptor tyrosine-based inhibition motifs (ITIM). CD172a/ SIRPα is expressed on CD34+ stem/progenitor cells, cardiomyocytes, monocytes, macrophages, granulocytes, dendritic cells, and in the central nervous system. It binds to CD47 and is implicated in mediating inhibitory signals via the ITIM/SHP-2 association. CD172b/ SIRPβ to cellular activation signaling . CD172b is expressed on myeloid cells, including peripheral blood monocytes and granulocytes. It is not expressed on CD34+ cells. CD172a and CD172b have complementary role s in signal regulation and may work together in tuning certain cellular responses to stimuli.

Specifications

Specifications

CD172a/b
SE5A5
SIRP alpha/beta1; SIRPα/SIRPβ1; Signal Regulatory Protein α/β1
Affinity Purified
Human SIRP alpha extracellular domain Recombinant Protein
100 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
PE
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Murine
IgG1, κ
RUO
Primary
Human
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