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CD172B Mouse anti-Human, BB515, Clone: B4B6, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 565092

Catalog No. BDB565092


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Description

Description

The B4B6 monoclonal antibody specifically binds to CD172b, which is also known as S ignal regulatory protein β (SIRPβ) , or SIRP-beta-1 (SIRPB1/SIRP β 1). CD172b is a 50 kDa, type I transmembrane glycoprotein that belongs to the SIRP family within the Ig gene superfamily. CD172b has a transmembrane domain that contains a positively-charged lysine residue. This allows CD172b to interact with a transmembrane signaling adaptor protein, DAP12/KARAP, and transduce stimulatory signals into cells. CD172b is expressed on monocytes, macrophages, dendritic cells, and granulocytes. It is not expressed on CD34+ cells. CD172b/SIRPβ and its counterpart, CD172a/SIRP α , appear to have complementary roles in signal regulation and may work together in tuning cellular responses to certain ligands.

Specifications

Specifications

CD172b
B4B6
SIRPB1; SIRP-BETA-1; SIRPβ1; SIRPbeta; SIRP beta
Affinity purified
Human SIRPβ1 extracellular domain Recombinant Protein
50 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
BB515
Aqueous buffered solution containing ≤0.09% sodium azide
Murine
IgG1, κ
RUO
Primary
Human
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