CD172B Mouse anti-Human, BB515, Clone: B4B6, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 565092
The B4B6 monoclonal antibody specifically binds to CD172b, which is also known as S ignal regulatory protein β (SIRPβ) , or SIRP-beta-1 (SIRPB1/SIRP β 1). CD172b is a 50 kDa, type I transmembrane glycoprotein that belongs to the SIRP family within the Ig gene superfamily. CD172b has a transmembrane domain that contains a positively-charged lysine residue. This allows CD172b to interact with a transmembrane signaling adaptor protein, DAP12/KARAP, and transduce stimulatory signals into cells. CD172b is expressed on monocytes, macrophages, dendritic cells, and granulocytes. It is not expressed on CD34+ cells. CD172b/SIRPβ and its counterpart, CD172a/SIRP α , appear to have complementary roles in signal regulation and may work together in tuning cellular responses to certain ligands.
|SIRPB1; SIRP-BETA-1; SIRPβ1; SIRPbeta; SIRP beta|
|Human SIRPβ1 extracellular domain Recombinant Protein|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Aqueous buffered solution containing ≤0.09% sodium azide|
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