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CD18 Mouse anti-Human, APC, Clone: MEM-48, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119456

Catalog No. 01-676-191


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Description

Description

This antibody recognizes an epitope involving residues 534-546 in cysteine-rich repeat 3 of the CD18 antigen (integrin beta2 subunit; beta2 integrin). It will not cross-react with canine.

CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leucocytes. CD18 can combine with integrin molecules CD11a-c to form heterodimers at the cell surface, and these heterodimers are known to participate in the process of cell adhesion as well as cell-surface mediated signaling. CD18 forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits, and these integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1, severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis. Defects in the CD18 gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the CD18 protein have been identified.
Specifications

Specifications

CD18
Monoclonal
APC
ITGB2
Liquid
ITGB2
Leucocytes from a patient suffering from a LGL type leukaemia.
Purified
RUO
Antibody
Monoclonal
Human
Flow Cytometry
MEM-48
PBS with 0.2% BSA and 15mM sodium azide
P05107
Cd18, LAD, LCAMB, Lfa1, MF17, Integrin beta-2 subunit, ITGB2, cluster designation 18
Mouse
IgG1
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
3689
Documents
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