Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

CD18 Mouse anti-Human, Clone: MEM-148, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119017

Catalog No. 01-674-990


Add to cart

Description

Description

This antibody will not cross-react with porcine. Endotoxin level is less than 0.01 EU/ug of the protein, as determined by the LAL test. Purity is >95% by SDS-PAGE. Western blot should be performed under non-reducing conditions.

CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leucocytes. CD18 can combine with integrin molecules CD11a-c to form heterodimers at the cell surface, and these heterodimers are known to participate in the process of cell adhesion as well as cell-surface mediated signaling. CD18 forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits, and these integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1, severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis. Defects in the CD18 gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the CD18 protein have been identified.
Specifications

Specifications

CD18
Monoclonal
1 mg/mL
PBS with no preservative; pH 7.4
P05107
Cd18, LAD, LCAMB, Lfa1, MF17, Integrin beta-2 subunit, ITGB2, cluster designation 18
Mouse
IgG1
100 μg
4° C, do not freeze
Primary
3689
Flow Cytometry, Functional Assay, Immunoprecipitation, Western Blot
MEM-148
Unconjugated
ITGB2
Liquid
ITGB2
Peripheral blood mononuclear cells.
Protein A
RUO
Antibody
Monoclonal
Human
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit