CD180 Rat anti-Mouse, Biotin, Clone: RP/14, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA140035
MA1-40035 detects CD180 from mouse samples. MA1-40035 has been successfully used in flow cytometry applications. The MA1-40035 immunogen is mouse RP105/CD180.Radioprotective 105 (RP105, CD180) is a 105 kDa type 1 transmembrane protein consisting of extracellular leucine-rich repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to Drosophila Toll in the extracellular LLRs. Radioprotective 105 (RP105, CD180) expression is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody-mediated (RP/14) cross-linking of RP105 induces resistance against irradiation-induced apoptosis, B-cell proliferation, and up-regulation of a costimulatory molecule B7.2, revealing RP105 as a potent regulator of B-cell activation. RP105 (CD180) has an important role in B-cell activation by LPS. It is important to note that RP105 associates with MD1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. MD-1 seems to be requisite for efficient expression of RP105.
|PBS with 0.1% BSA and 0.02% sodium azide|
|LY64, Ly78, CD180 antigen, lymphocyte antigen 64, lymphocyte antigen-64 radioprotective, radioprotective 105 kDa protein|
|Flow Cytometry, Functional Assay|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok