CXCR4 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112542
A suggested positive control for this product is HeLa cell lysate.Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to T-cell antigen T4 (CD4), to infect target cells. Some G protein-coupled receptors including chemokine (C-C) receptor 5 (CCR5), chemokine (C-X-C) receptor 4 (CXCR4), CCR3, CCR2b, and CCR8 in the chemokine receptor family, and four new human molecules G-protein coupled receptor 15 (GPR15), CXCR6, GPR1, and chemokine (C-X3-C) receptor 1 (CX3CR1) were recently identified as HIV coreceptors. Among them, CXCR4 (fusin, LESTR, or HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The alpha-chemokine stromal cell-derived factor-1 (SDF-1) is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlate with HIV-1 permissiveness in diverse human cell types. Some antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites.
|Synthetic peptide corresponding to residues 182-196 of CXCR4 receptor.|
|Antigen affinity chromatography|
|PBS with 0.02% sodium azide|
|D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, C-X-C chemokine receptor type 4|
|-20° C, Avoid Freeze/Thaw Cycles|
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