CD22 Mouse anti-Human, Non-human primate, PE, Clone: MEM-01, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119642
CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.
|Burkitt′s lymphoma cell line Raji.|
|Human, Non-human Primate|
|PBS with 0.2% BSA and 15mM sodium azide|
|FLJ22814, MGC130020, SIGLEC-2, SIGLEC2, B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, CD22 antigen, T-cell surface antigen Leu-14, sialic acid binding Ig-like lectin 2, sialic acid-binding Ig-like lectin 2|
|4° C, store in dark, DO NOT FREEZE!|
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