CD220 (Insulin Receptor β) Rabbit anti-Rat, Unlabeled, Polyclonal, BD
Rabbit Polyclonal Antibody
Manufacturer: BD Biosciences 611276
The Insulin Receptor (IR), also known as CD220, is a transmembrane receptor tyrosine kinase which, upon insulin binding, initiates a cascade of events, including autophosphorylation, phosphorylation of cellular protein substrates, glucose transport, and glycogen synthesis. IR is synthesized as a large glycosylated precursor that is cleaved upon maturation into a 130kDa α-subunit with kinase activity and a 95kDa β-chain. The active Insulin Receptor is a heterotetramer of homologous α and β subunits joined by disulfide bonds. Among the major cytosolic substrates of the Insulin Receptor are IRS-1 and -2, β-Adrenergic receptor, and pp15 (adipocyte lipid-binding protein, ALBP). Autophosphorylation of the IR recruits IRS-1 and -2 act as docking sites for other signaling proteins like PI3-Kinase, Shc, PTP1D, Nck, etc. In addition, the phosphatase LAR is tightly associated with the IR and LAR becomes activated after insulin stimulation dephosphorylating the IR and its substrates. Therefore, LAR provides a turn-off mechanism in insulin signaling.
Species Reactivity: Rat
Formula Weight [Chemical]: 95kDa
Immunofluorescence, Western Blotting
|CD220 (Insulin Receptor β)|
|Immunofluorescence, Western Blot|
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