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IGF2R Mouse anti-Human, Non-human primate, Clone: MEM-238, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119252

Catalog No. 01-676-016


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Description

Description

This antibody recognizes an epitope between domains 2 and 5 of CD222 (IGF2 receptor), a ubiquitously expressed 250 kDa multifunctional type I transmembrane protein. The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10% in the plasma membrane and the truncated (220 kDa) form of CD222 is present in human and bovine serum. Western blot should be performed under non-reducing conditions.

CD222 (CIMPR, cation-independent mannose 6-phosphate receptor; IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria.
Specifications

Specifications

IGF2R
Monoclonal
1 mg/mL
PBS with 15mM sodium azide; pH 7.4
P11717
CD222, CIMPR, M6P-R, MPR1, MPRI, 300 kDa mannose 6-phosphate receptor, CI Man-6-P receptor, CI-MPR, IGF-II receptor, M6P/IGF2 receptor, M6P/IGF2R, IGF2R
Mouse
IgG1
100 μg
4° C, do not freeze
Primary
3482
Flow Cytometry, Western Blot
MEM-238
Unconjugated
IGF2R
Liquid
IGF2R
Recombit Vaccinia virus encoding CD222.
Protein A
RUO
Antibody
Monoclonal
Human, Non-human Primate
Documents
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