IGF2R Mouse anti-Human, Non-human primate, Clone: MEM-238, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119252
This antibody recognizes an epitope between domains 2 and 5 of CD222 (IGF2 receptor), a ubiquitously expressed 250 kDa multifunctional type I transmembrane protein. The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10% in the plasma membrane and the truncated (220 kDa) form of CD222 is present in human and bovine serum. Western blot should be performed under non-reducing conditions.CD222 (CIMPR, cation-independent mannose 6-phosphate receptor; IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria.
|PBS with 15mM sodium azide; pH 7.4|
|CD222, CIMPR, M6P-R, MPR1, MPRI, 300 kDa mannose 6-phosphate receptor, CI Man-6-P receptor, CI-MPR, IGF-II receptor, M6P/IGF2 receptor, M6P/IGF2R, IGF2R|
|4° C, do not freeze|
|Flow Cytometry, Western Blot|
|Recombit Vaccinia virus encoding CD222.|
|Human, Non-human Primate|
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