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CD25 Mouse anti-Human, Biotin, Clone: MEM-181, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119493

Catalog No. 01-676-227


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Description

Description

CD25 (IL2Ralpha, Tac) is a ligand-binding alpha subunit of interleukin 2 receptor (IL2R). Together with beta and gamma subunit CD25 constitues the high affinity IL2R, whereas CD25 alone serves as the low affinity IL2R. CD25 expression rapidly increases upon T cell activation. The 55kDa CD25 molecule is enzymatically cleaved and shed from the cell surface as a soluble 45kDa s-Tac, whose concentration in serum can be used as a marker of T cell activation. Expression of CD25 indicates the neoplastic phenotype of mast cells. Humanized anti CD25 antibodies represent a useful tool to reduce the incidence of allograft rejection as well as the severity of graft versus host reaction, and radioimmunoconjugates of anti-CD25 antibodies can be used against CD25 expressing lymphomas.

Specifications

Specifications

CD25
Monoclonal
Biotin
IL2RA
Liquid
IL2RA
PHA-activated peripheral blood leucocytes.
Purified
RUO
Antibody
Monoclonal
Human
Flow Cytometry
MEM-181
PBS with 15mM sodium azide; pH 7.4
P01589
IL2 RA antibody, Il2ra antibody, Interleukin 2 receptor alpha chain antibody, TAC antigen antibody, IL-2R alpha chain
Mouse
IgG1
100 μg
4° C, do not freeze
Primary
3559
Documents
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