CD268 (BAFF Receptor) Mouse anti-Human, Brilliant Violet 421, Clone: 11C1, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 564819
Monoclonal antibody 11C1 reacts with the B cell activating factor receptor (BAFF-R), a type III transmembrane protein of approximately 184 residues. BAFF-R is one of the receptors for B-cell activating factor (BAFF), a member of the TNF family of proteins. BAFF is a key regulator for B cell differentiation and critical in regulating survival and activation of peripheral B cell populations. Experiments in the mouse model show that interaction of BAFF with BAFF-R promotes NF- κ B activity. Overexpression of BAFF results in an expanded B cell compartment and autoimmunity in mice. Mice injected with BAFF-neutralizing-Fc (BAFF-R-Fc) protein showed reduced NF- κ B activation, blocking BAFF-induced B cell proliferation. Reports suggest that the BAFF-BAFF-R interaction may lead to a better understanding of autoimmune disorders.
|CD268 (BAFF Receptor)|
|BAFF Receptor; BAFF-R; BLyS receptor 3; BR3; TNFRSF13C|
|Human BAFF-R Transfected Cell Line|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Brilliant Violet 421|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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