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CD268 (BAFF Receptor) Mouse anti-Human, Brilliant Violet 421, Clone: 11C1, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 564819

Catalog No. BDB564819

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Monoclonal antibody 11C1 reacts with the B cell activating factor receptor (BAFF-R), a type III transmembrane protein of approximately 184 residues. BAFF-R is one of the receptors for B-cell activating factor (BAFF), a member of the TNF family of proteins. BAFF is a key regulator for B cell differentiation and critical in regulating survival and activation of peripheral B cell populations. Experiments in the mouse model show that interaction of BAFF with BAFF-R promotes NF- κ B activity. Overexpression of BAFF results in an expanded B cell compartment and autoimmunity in mice. Mice injected with BAFF-neutralizing-Fc (BAFF-R-Fc) protein showed reduced NF- κ B activation, blocking BAFF-induced B cell proliferation. Reports suggest that the BAFF-BAFF-R interaction may lead to a better understanding of autoimmune disorders.

Specifications

Specifications

CD268 (BAFF Receptor)
11C1
BAFF Receptor; BAFF-R; BLyS receptor 3; BR3; TNFRSF13C
Affinity Purified
Human BAFF-R Transfected Cell Line
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
RUO
Primary
Human
Flow Cytometry
Brilliant Violet 421
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Murine
IgG1, κ
50 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Documents
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