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CD268 (BAFF Receptor) Mouse anti-Human, Brilliant Violet 421, Clone: 11C1, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 564819

Catalog No. BDB564819

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.



Monoclonal antibody 11C1 reacts with the B cell activating factor receptor (BAFF-R), a type III transmembrane protein of approximately 184 residues. BAFF-R is one of the receptors for B-cell activating factor (BAFF), a member of the TNF family of proteins. BAFF is a key regulator for B cell differentiation and critical in regulating survival and activation of peripheral B cell populations. Experiments in the mouse model show that interaction of BAFF with BAFF-R promotes NF- κ B activity. Overexpression of BAFF results in an expanded B cell compartment and autoimmunity in mice. Mice injected with BAFF-neutralizing-Fc (BAFF-R-Fc) protein showed reduced NF- κ B activation, blocking BAFF-induced B cell proliferation. Reports suggest that the BAFF-BAFF-R interaction may lead to a better understanding of autoimmune disorders.



CD268 (BAFF Receptor)
BAFF Receptor; BAFF-R; BLyS receptor 3; BR3; TNFRSF13C
Affinity Purified
Human BAFF-R Transfected Cell Line
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Flow Cytometry
Brilliant Violet 421
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
IgG1, κ
50 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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