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CD274 Mouse anti-Human, Brilliant Violet 650, Clone: MIH1, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 563740

Catalog No. BDB563740

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PD-L1 and PD-L2 are newly discovered members of the B7 family are the ligands for the program death 1 (PD-1) receptor. They are expressed on immature dendritic cells and mature dendritic cells. PD-L1 is expressed on antigen-presenting cells, including monocytes stimulated with IFN- γ, and activated human and murine dendritic cells. Monoclonal antibodies that block PD-L1 and PD-L2 on dendritic cells result in enhance T cell proliferation and cytokine production. PD-L1 is also expressed on placental trophoblasts, myocardial endothelium, cortical thymic epithelial cells, and on most carcinomas. Studies show overlapping functions of PD-L1 and PD-L2 and indicate an important role for the PD-L:PD-1 pathway in regulating T cell responses.

The antibody was conjugated to BD Horizon™ BV650 which is part of the BD Horizon Brilliant Violet™ family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 650-nm. BD Horizon BV650 can be excited by the violet laser and detected in a filter used to detect APC-like dyes (eg, 660/20-nm filter). Due to the excitation and emission characteristics of the acceptor dye, there will be spillover into the APC and Alexa Fluor™ 700 detectors. However, the spillover can be corrected through compensation as with any other dye combination.



B7-H1, PD-L1
Affinity Purified
Human CD274 Transfected Cell Line
100 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Flow Cytometry
Brilliant Violet 650
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
IgG1, κ
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