B7-H3, clone: MIH42, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA174441

Catalog No. PIMA174441

Description

CD276 is a member of the B7 family of co-stimulatory molecules also known as B7-H3. CD276 is a type I transmembrane protein that induces the proliferation of CD4+ and CD8+ T cells, enhances the generation of cytotoxic T cells and selectively stimulates the production of interferon gamma. Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines, and is also widely expressed in peripheral tissues including the heart, kidney, testis and colon. In humans, CD276 exists as two isoforms which result from gene duplication and differential splicing. CD276 is reported to have therapeutic potential for the regulation of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy.

For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul. A suggested positive control for immunohistochemical applications is acetone-fixed human tonsil.

Specifications

• Antigen: B7-H3/CD276
• Classification: Monoclonal
• Concentration: 1mg/mL
• Gene: CD276
• Gene Alias: PSEC0249, 4Ig-B7-H3, B7-H3, B7H3, B7RP-2, B7 homolog 3, CD276 antigen, costimulatory molecule
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 80381
• Content And Storage: Store at 4°C or Store at -20°C if preferred
• Form: Purified

• Applications: Flow Cytometry, Immunohistochemistry (Frozen)
• Clone: MIH42
• Conjugate: Unconjugated
• Gene Accession No.: Q5ZPR3
• Gene Symbols: CD276
• Immunogen: Contact ABR for details.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1