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CD28 Monoclonal Antibody (B-23), APC, Invitrogen™
Mouse Monoclonal Antibody
Supplier: Thermo Scientific MA112260
Description
CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary’s Disease.Specifications
CD28 | |
Monoclonal | |
APC | |
P10747 | |
CD28 | |
HPB-ALL T-cell line | |
100 Tests | |
Primary | |
Human | |
Antibody | |
IgG1 |
Flow Cytometry | |
B-23 | |
CD28 | |
MGC138290, Tp44, CD28 antigen, T-cell-specific surface glycoprotein CD28 | |
Mouse | |
Protein A/G | |
RUO | |
940 | |
4° C, do not freeze | |
Liquid |
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