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CD28 Mouse anti-Human, APC, Clone: B-23, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112260

Catalog No. 01-670-956


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Description

Description

CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary’s Disease.
Specifications

Specifications

CD28
Monoclonal
APC
CD28
Liquid
CD28
HPB-ALL T-cell line
Protein A/G
RUO
Antibody
Monoclonal
Human
Flow Cytometry
B-23
PBS with 0.2% carrier protein and 0.08% sodium azide
P10747
MGC138290, Tp44, CD28 antigen, T-cell-specific surface glycoprotein CD28
Mouse
IgG1
100 Tests
4° C, do not freeze
Primary
940
Documents
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