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CD28 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA14144

Catalog No. PA14144


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Description

Description

PA1-4144 detects CD28 in human samples. PA1-4144 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~27 kDa protein representing CD28 in CD4 cells. The PA1-4144 immunogen is a synthetic peptide corresponding to residues S(72) Q Q L Q V Y S K T G F N(85), which is the Ig-V-like region of human CD28.

CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary’s Disease.
Specifications

Specifications

CD28
Polyclonal
Unconjugated
CD28
Liquid
CD28
Synthetic peptide corresponding to residues S(72) Q Q L Q V Y S K T G F N(85), which is the Ig-V-like region of human CD28.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P10747
MGC138290, Tp44, CD28 antigen, T-cell-specific surface glycoprotein CD28
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
940
Documents
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