TLR4 Rabbit anti-Human, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112824
A suggested positive control for this product is placenta, spleen or peripheral blood leukocytes.Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) á/â and NF- êB (4-6). Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.
|Synthetic peptide corresponding to 15 residues near the N-terminus of human TLR4.|
|Antigen affinity chromatography|
|Immunocytochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|Toll-like Receptor 4, ARMD10, CD284, TLR-4, TOLL, hToll, homolog of Drosophila toll|
|-20° C, Avoid Freeze/Thaw Cycles|
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