CD2AP Rabbit anti-Human, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA528391
PA5-28391 targets CD2AP in IF, IHC (P), and WB applications and shows reactivity with Human samples. The PA5-28391 immunogen is recombit fragment corresponding to a region within amino acids 1 and 281 of Human CD2AP. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
|Recombit fragment corresponding to a region within amino acids 1 and 281 of Human CD2AP|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7|
|CMS, Cas ligand with multiple Src homology 3 SH3 domains, adapter protein CMS, cas ligand with multiple SH3 domains|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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