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CD3/CD28 Mouse anti-Human, FITC, PE, Invitrogen™

Antibody Cocktail

Manufacturer:  Invitrogen MA112097

Catalog No. 01-670-816


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Description

Description

This antibody is a monoclonal mixture of FITC-conjugated CD3 (clone M2AB, isotype IgG1) and PE-conjugated CD28 (clone B-23, isotype IgG1).

T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. Human CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. It is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes (approximately 95% of CD4+ cells and 50% of CD8+ cells). Mature thymocytes exhibit higher levels of CD28 than the immature cells. Activation of T cells results in enhanced CD28 expression. T cell activation requires two combined signals provided by antigen presenting cells.
Specifications

Specifications

CD3/CD28
Cocktail
FITC, PE
CD3E
Liquid
CD28, CD3D, CD3E, CD3G
human thymocytes and HPB-ALL T-cell line
Protein A/G
RUO
Antibody
915, 916, 917, 940
Flow Cytometry
M2AB, B-23
PBS with 0.2% carrier protein and 0.08% sodium azide
P04234, P07766, P09693, P10747
CD3e, CD3 epsilon, FLJ18683, T3E, TCRE, CD3-epsilon, CD3e antigen, epsilon polypeptide TiT3 complex, T-cell antigen receptor complex, epsilon subunit of T3, T-cell surface antigen T3/Leu-4 epsilon chain, T-cell surface glycoprotein CD3 epsilon chain, MGC138290, Tp44, CD28 antigen, T-cell-specific surface glycoprotein CD28
Mouse
IgG1
100 Tests
4° C, do not freeze
Primary
Human
Documents
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