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CD3 Mouse anti-Rat, Unlabeled, Clone: G4.18, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 559974

Catalog No. BDB559974


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Description

Description

The G4.18 antibody reacts with the T-cell receptor-associated CD3 cell-surface antigen found on thymocytes, peripheral T lymphocytes, and dendritic epidermal T cells. It has been reported that CD3 expression is down-regulated within 24 hours in concanavalin A-stimulated rat T cells, and soluble mAb inhibits the allogeneic mixed-lymphocyte proliferative response and cell-mediated cytotoxicity to allogeneic target cells. In vivo treatment with G4.18 mAb prevents cardiac and skin allograft rejection, resulting in donor-specific tolerance. Pre-incubation of splenocytes with the alternate anti-rat CD3 monoclonal antibody, 1F4 (Cat. No. 556970), blocks staining with mAb G4.18.

Specifications

Specifications

CD3
G4.18
Unconjugated
Affinity Purified
PHA-stimulated rat lymph node and spleen cells
0.1mg
Store undiluted at 4°C
Monoclonal
Flow Cytometry
0.5mg/mL
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Mouse
IgG3, κ
RUO
Primary
Rat
SDS
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