CD3 Mouse anti-Human, Clone: ICO-90, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA17640
MA1-7640 detects CD3 from human samples. MA1-7640 has been successfully used in flow cytometry procedures. The MA1-7640 immunogen is T-cells.The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
|PBS with 0.2% gelatin, 0.5% saccharose and 0.01% sodium azide|
|CD3-DELTA; T3D; CD3 antigen; delta subunit; CD3 delta; CD3d antigen; delta polypeptide TiT3 complex; OKT3; delta chain; T-cell receptor T3 delta chain; T-cell surface glycoprotein CD3 delta chain; HCD3|
|4°C or -80°C if preferred|
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